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<p>This study investigated the impact of childhood sexual abuse (CSA) on brain responses to aversive stimuli in patients with Posttraumatic Stress Disorder (PTSD). Whole-brain and regions-of-interest analyses revealed that participants who reported higher severity of CSA had smaller brain reactivity to mutilation versus neutral pictures in the right postcentral and supramarginal gyrus, and in the left midcingulate, suggesting that CSA may blunt brain reactivity to aversive stimuli in areas involved in sensory and emo-motoric processing. This study adds evidence for long-lasting effects of CSA on brain processing and attests the need for specific diagnosis and treatment for the affected patients with PTSD.</p>

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Blunted Brain Reactivity To Mutilation Pictures in Patients with Posttraumatic Stress Disorder and Exposure To Childhood Sexual Abuse: An fMRI Study

  • 期刊论文

  • 发表日期：

    2025年11月10日

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  • Aline F. Bastos,
  • Leticia de Oliveira,
  • Mirtes G. Pereira,
  • Mauro V. Mendlowicz,
  • William Berger,
  • Aline R. Cardoso,
  • Eliane Volchan,
  • Fatima S. Erthal

摘要

This study investigated the impact of childhood sexual abuse (CSA) on brain responses to aversive stimuli in patients with Posttraumatic Stress Disorder (PTSD). Whole-brain and regions-of-interest analyses revealed that participants who reported higher severity of CSA had smaller brain reactivity to mutilation versus neutral pictures in the right postcentral and supramarginal gyrus, and in the left midcingulate, suggesting that CSA may blunt brain reactivity to aversive stimuli in areas involved in sensory and emo-motoric processing. This study adds evidence for long-lasting effects of CSA on brain processing and attests the need for specific diagnosis and treatment for the affected patients with PTSD.