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<p>Diagnosing food allergies requires a&#xa0;well-considered approach from the very first step. The reason for this is the frequent presence of clinically irrelevant immunoglobulin&#xa0;E (IgE) sensitizations in a&#xa0;large proportion of individuals. Equating sensitization detected by skin prick tests or the detection of specific IgE antibodies with clinical relevance can lead to the misdiagnosis of an allergy. Therefore, a&#xa0;thorough patient history is essential as the foundation of the diagnostic process. Another reason is the high rate of self-suspected allergies among patients due to a&#xa0;lack of understanding of the typical symptoms of food allergies. Patients assume that unspecific symptoms or skin changes are the result of food intolerance. However, food allergies trigger clearly defined symptoms that are often easy to ask about. The physician’s task is, therefore, to separate implausible from plausible symptoms by taking a&#xa0;thorough medical history and then subsequently plan a&#xa0;targeted diagnostic work-up. In doing so, the limitations and diagnostic potential of serological testing using allergen extracts and components, as well as those of skin testing, must be clearly understood. This article provides a&#xa0;concise summary of the essential steps in the diagnosis of food allergy.</p>

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Diagnosis of food allergies

  • 期刊论文

  • 发表日期：

    2025年6月26日

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  • Lars Lange

摘要

Diagnosing food allergies requires a well-considered approach from the very first step. The reason for this is the frequent presence of clinically irrelevant immunoglobulin E (IgE) sensitizations in a large proportion of individuals. Equating sensitization detected by skin prick tests or the detection of specific IgE antibodies with clinical relevance can lead to the misdiagnosis of an allergy. Therefore, a thorough patient history is essential as the foundation of the diagnostic process. Another reason is the high rate of self-suspected allergies among patients due to a lack of understanding of the typical symptoms of food allergies. Patients assume that unspecific symptoms or skin changes are the result of food intolerance. However, food allergies trigger clearly defined symptoms that are often easy to ask about. The physician’s task is, therefore, to separate implausible from plausible symptoms by taking a thorough medical history and then subsequently plan a targeted diagnostic work-up. In doing so, the limitations and diagnostic potential of serological testing using allergen extracts and components, as well as those of skin testing, must be clearly understood. This article provides a concise summary of the essential steps in the diagnosis of food allergy.