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Background <p>Although excessive alcohol consumption is a critical factor for non-communicable diseases, its clinical relevance to chronic kidney disease is controversial.</p> Methods <p>This retrospective cohort study, including 80,765 men and 88,507 women aged 40–74&#xa0;years who underwent annual health checkups in Japan between April 2012 and March 2017, assessed a dose-dependent association between alcohol consumption (rare, occasional, and daily drinkers with ≤ 19, 20–39, 40–59, and ≥ 60&#xa0;g/day) and incidence of ≥ 30% decline in estimated glomerular filtration rate (eGFR), eGFR &lt; 60&#xa0;ml/min/1.73 m<sup>2</sup> and&#xa0;presence of proteinuria (dipstick urinary protein ≥ 1 +), using Cox proportional hazards models adjusted for clinically relevant factors.</p> Results <p>The incidence of ≥ 30% eGFR decline was observed in 1231 (1.5%) men and 1291 (1.5%) women during the median observation period of 2.8 and 2.9&#xa0;years, respectively. In men, daily drinkers consuming ≥ 40&#xa0;g/day of ethanol were at significantly high risk for ≥ 30% eGFR decline (adjusted hazard ratio [95% confidence interval] of rare, occasional, and daily drinkers with ≤ 19, 20–39, 40–59, and ≥ 60&#xa0;g/day: 1.00 [reference], 1.05 [0.87, 1.27], 0.99 [0.80, 1.21], 1.05 [0.88, 1.26], 1.23 [1.01, 1.51], 1.61 [1.22, 2.11], respectively). Similar dose-dependent associations with incidence of eGFR &lt; 60&#xa0;ml/min/1.73 m<sup>2</sup> and proteinuria were observed in men. Contrary to men, alcohol consumption was not associated with eGFR decline and proteinuria in women.</p> Conclusion <p>Men with alcohol consumption ≥ 40&#xa0;g/day were at a high risk of eGFR decline and development of&#xa0;proteinuria.</p> Graphical abstract <p></p>

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Alcohol consumption and incidence of decline in glomerular filtration rate and of proteinuria: the Osaka Kenko Innovation (TOKI) study

  • 期刊论文

  • 发表日期：

    2025年7月13日

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  • Yuko Nakamura,
  • Naoko Otsuki,
  • Qinyan Li,
  • Maki Shinzawa,
  • Isao Matsui,
  • Miyae Yamakawa,
  • Asuka Oyama,
  • Hiroshi Toki,
  • Ryohei Yamamoto

摘要

Background

Although excessive alcohol consumption is a critical factor for non-communicable diseases, its clinical relevance to chronic kidney disease is controversial.

Methods

This retrospective cohort study, including 80,765 men and 88,507 women aged 40–74 years who underwent annual health checkups in Japan between April 2012 and March 2017, assessed a dose-dependent association between alcohol consumption (rare, occasional, and daily drinkers with ≤ 19, 20–39, 40–59, and ≥ 60 g/day) and incidence of ≥ 30% decline in estimated glomerular filtration rate (eGFR), eGFR < 60 ml/min/1.73 m2 and presence of proteinuria (dipstick urinary protein ≥ 1 +), using Cox proportional hazards models adjusted for clinically relevant factors.

Results

The incidence of ≥ 30% eGFR decline was observed in 1231 (1.5%) men and 1291 (1.5%) women during the median observation period of 2.8 and 2.9 years, respectively. In men, daily drinkers consuming ≥ 40 g/day of ethanol were at significantly high risk for ≥ 30% eGFR decline (adjusted hazard ratio [95% confidence interval] of rare, occasional, and daily drinkers with ≤ 19, 20–39, 40–59, and ≥ 60 g/day: 1.00 [reference], 1.05 [0.87, 1.27], 0.99 [0.80, 1.21], 1.05 [0.88, 1.26], 1.23 [1.01, 1.51], 1.61 [1.22, 2.11], respectively). Similar dose-dependent associations with incidence of eGFR < 60 ml/min/1.73 m2 and proteinuria were observed in men. Contrary to men, alcohol consumption was not associated with eGFR decline and proteinuria in women.

Conclusion

Men with alcohol consumption ≥ 40 g/day were at a high risk of eGFR decline and development of proteinuria.

Graphical abstract