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<p>Zoledronic acid is the most powerful among bisphosphonates with the longest effect on bone. This is mainly caused by a number of factors, including avid uptake by skeletal tissue and greater inhibition of enzyme farnesyl pyrophosphate synthase in the mevalonate pathway, A number of schedule administrations have been suggested, based on its ability to decrease bone resorption for a long period of time. It is the bisphosphonate of choice in avoiding the rebound phenomenon in patients discontinuing denosumab.</p>

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Acido zoledronico: trattamento e prevenzione dell’osteoporosi

  • 期刊论文

  • 发表日期：

    2026年6月16日

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  • Salvatore Minisola

摘要

Zoledronic acid is the most powerful among bisphosphonates with the longest effect on bone. This is mainly caused by a number of factors, including avid uptake by skeletal tissue and greater inhibition of enzyme farnesyl pyrophosphate synthase in the mevalonate pathway, A number of schedule administrations have been suggested, based on its ability to decrease bone resorption for a long period of time. It is the bisphosphonate of choice in avoiding the rebound phenomenon in patients discontinuing denosumab.