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<p>Pregnancy and Lactation-Associated Osteoporosis (PLAO) is a condition of skeletal fragility typically manifesting as multiple vertebral fractures during the third trimester or lactation. Its incidence is likely underestimated. Clinical workup necessitates ruling out secondary causes and assessing bone mineral density. Initial management involves optimising calcium intake, vitamin D supplementation and the cessation of breastfeeding. Pharmacotherapy (off-label) remains controversial; it is recommended to await spontaneous recovery and reserve anabolic agents only for severe cases or those with insufficient recovery.</p>

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Osteoporosi associata a gravidanza e allattamento (PLAO)

  • 期刊论文

  • 发表日期：

    2026年5月6日

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  • Marta Zampogna,
  • Giorgia Grassi,
  • Giovanna Mantovani,
  • Cristina Eller Vainicher

摘要

Pregnancy and Lactation-Associated Osteoporosis (PLAO) is a condition of skeletal fragility typically manifesting as multiple vertebral fractures during the third trimester or lactation. Its incidence is likely underestimated. Clinical workup necessitates ruling out secondary causes and assessing bone mineral density. Initial management involves optimising calcium intake, vitamin D supplementation and the cessation of breastfeeding. Pharmacotherapy (off-label) remains controversial; it is recommended to await spontaneous recovery and reserve anabolic agents only for severe cases or those with insufficient recovery.