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<p>Bone metabolism and the coagulation system, once viewed as distinct physiological processes, are now recognised to be interconnected through a complex and dynamic bidirectional relationship. Several components of the haemostatic cascade have been shown to influence bone cell activity, while key regulators of mineral metabolism exert modulatory effects on vascular and haemostatic pathways. This interplay becomes particularly relevant in clinical practice, given the increasing prevalence and frequent coexistence of thrombotic and skeletal disorders, as well as the widespread use of therapies that may affect both systems. This review summarises the main molecular and cellular mechanisms underlying this crosstalk, also discussing some potential clinical implications.</p>

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Interazioni tra sistema coagulativo e metabolismo osseo: nuovi spunti fisiopatologici e terapeutici

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月7日

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  • Gaetano Paride Arcidiacono,
  • Elena Campello,
  • Marco Onofrio Torres,
  • Paolo Simioni,
  • Sandro Giannini,
  • Stefania Sella

摘要

Bone metabolism and the coagulation system, once viewed as distinct physiological processes, are now recognised to be interconnected through a complex and dynamic bidirectional relationship. Several components of the haemostatic cascade have been shown to influence bone cell activity, while key regulators of mineral metabolism exert modulatory effects on vascular and haemostatic pathways. This interplay becomes particularly relevant in clinical practice, given the increasing prevalence and frequent coexistence of thrombotic and skeletal disorders, as well as the widespread use of therapies that may affect both systems. This review summarises the main molecular and cellular mechanisms underlying this crosstalk, also discussing some potential clinical implications.