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<p>Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare clinical condition, predominantly affecting middle-aged women. It may be associated with specific histological lesions such as tumourlets and carcinoid tumours, often presenting with mild or absent respiratory symptoms. Diagnosis is based on chest CT and histological confirmation. Management is individualised and includes surveillance, bronchodilators, somatostatin analogues, everolimus, and, in severe cases, surgery or lung transplantation.</p>

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Iperplasia diffusa delle cellule polmonari neuroendocrine (DIPNECH): diagnosi e gestione clinica

  • 期刊论文

  • 发表日期：

    2025年9月2日

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  • Roberta Modica,
  • Elia Guadagno,
  • Massimo Di Nola,
  • Annamaria Colao

摘要

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare clinical condition, predominantly affecting middle-aged women. It may be associated with specific histological lesions such as tumourlets and carcinoid tumours, often presenting with mild or absent respiratory symptoms. Diagnosis is based on chest CT and histological confirmation. Management is individualised and includes surveillance, bronchodilators, somatostatin analogues, everolimus, and, in severe cases, surgery or lung transplantation.