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Introduction/purpose <p>Long‑acting growth hormone (LAGH) formulations have emerged to address poor adherence to daily recombinant human growth hormone (rhGH), offering reduced injection frequency and comparable efficacy. Though their efficacy and safety in children have been demonstrated in registrative trials and in some real-world studies, their impact on other pituitary axes remains unclear.</p> Methods <p>This observational prospective monocentric study explores hormonal changes in isolate growth hormone deficiency (GHD) children (<i>n</i> = 33) starting LAGH Somatrogon (<i>n</i> = 16, G1) or switching from daily rhGH to the same weekly analogue (<i>n</i> = 17, G2). In all study patients, baseline and post‑treatment assessments (after 3–6 months of weekly LAGH start) included IGF‑I, ACTH, cortisol, TSH, FT4 and FT3 levels.</p> Results <p>After LAGH initiation, IGF‑I SDS increased significantly in both groups (<i>p</i> &lt; 0.001), more frequently exceeding 2 SDS in G2 (6/17 vs. 2/16 in G1). No significant changes occurred in TSH, FT3, FT4, ACTH or cortisol levels after LAGH start, nor between‑group differences.</p> Conclusions <p>In isolated GHD, adrenal and thyroid function remained stable after LAGH initiation, with comparable results in treatment‑naïve patients and in those already receiving daily therapy. A greater increase in IGF-I levels was observed in switchers, suggesting that a lower starting dose may be appropriate in patients previously treated with rhGH. Further studies are required to clarify the endocrine effects of long‑acting formulations in individuals with associated multiple pituitary hormone deficiencies.</p>

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Influence of long-acting growth hormone analogs on other hypothalamic-pituitary axes: a real-world study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月29日

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  • Giulia Rodari,
  • Eriselda Profka,
  • Aurora Pedroli,
  • Valeria Citterio,
  • Valentina Collini,
  • Camilla Mazzi,
  • Giovanna Mantovani,
  • Claudia Giavoli

摘要

Introduction/purpose

Long‑acting growth hormone (LAGH) formulations have emerged to address poor adherence to daily recombinant human growth hormone (rhGH), offering reduced injection frequency and comparable efficacy. Though their efficacy and safety in children have been demonstrated in registrative trials and in some real-world studies, their impact on other pituitary axes remains unclear.

Methods

This observational prospective monocentric study explores hormonal changes in isolate growth hormone deficiency (GHD) children (n = 33) starting LAGH Somatrogon (n = 16, G1) or switching from daily rhGH to the same weekly analogue (n = 17, G2). In all study patients, baseline and post‑treatment assessments (after 3–6 months of weekly LAGH start) included IGF‑I, ACTH, cortisol, TSH, FT4 and FT3 levels.

Results

After LAGH initiation, IGF‑I SDS increased significantly in both groups (p < 0.001), more frequently exceeding 2 SDS in G2 (6/17 vs. 2/16 in G1). No significant changes occurred in TSH, FT3, FT4, ACTH or cortisol levels after LAGH start, nor between‑group differences.

Conclusions

In isolated GHD, adrenal and thyroid function remained stable after LAGH initiation, with comparable results in treatment‑naïve patients and in those already receiving daily therapy. A greater increase in IGF-I levels was observed in switchers, suggesting that a lower starting dose may be appropriate in patients previously treated with rhGH. Further studies are required to clarify the endocrine effects of long‑acting formulations in individuals with associated multiple pituitary hormone deficiencies.