Background <p>Compared to other U.S. racial/ethnic groups, Native Americans (NAs) have a greater likelihood of developing chronic pain. Considering this inequity, it is important to understand which coping strategies are associated with pain intensity and interference for NAs.</p> Purpose <p>The present study explored whether three coping strategies were associated with pain intensity and interference, and whether they moderated the impact of pain intensity on pain interference.</p> Methods <p>NAs with chronic pain (<i>N</i> = 103) completed surveys that assessed past week average pain intensity (11-point numerical rating scale), past week pain interference (Brief Pain Inventory, extended version), and task persistence, resting, and coping self-statements (Chronic Pain Coping Inventory). Regression analyses were used to predict pain intensity and interference from coping strategies, after controlling for age, sex, education, and income.</p> Results <p>Greater use of coping self-statements (<i>p</i>=.013) and lower income (<i>p</i>=.023) were associated with higher pain intensity. Higher pain intensity (<i>p</i>&lt;.001), greater use of coping-self statements (<i>p</i>=.031), and lower task persistence (<i>p</i>=.003) were associated with more pain interference. No strategy moderated the relationship between pain intensity and pain interference (<i>p</i>s &gt; 0.05).</p> Conclusions <p>These results suggest task persistence may help mitigate the impact of NA chronic pain, regardless of experienced pain intensity. By contrast, coping self-statements were not associated with chronic pain consequences.</p>