Objectives <p>COVID-19 contributed to decreases in physical activity and residents from communities with more crime and fewer resources were less physically active during the pandemic. However, the direct effects of COVID-related increases in crime on leisure-time physical activity has not been studied, extensively. Therefore, we examined how individual perceptions of neighborhood violence, community-level perceptions of safety, and the prevalence of violent crime are associated with leisure-time physical activity across neighborhoods in Chicago, Illinois, following the COVID-19 stay-at-home order.</p> Methods <p>We used cross-sectional data to build a multilevel logistic regression model in which the individual represented level 1 and the Chicago community area represented level 2. We used a stepwise approach, testing variables, one at a time, as random intercepts and then as random coefficients. We estimated adjusted odds ratios and 95% confidence intervals.</p> Results <p>Respondents who reported violence occurring every day had significantly lower odds of leisure-time physical activity (OR = 0.65, 95% CI = 0.50—0.85). Compared to non-Hispanic Whites, Non-Hispanic Blacks (OR = 0.75, 95% CI = 0.57 – 0.99), non-Hispanic Asian American/Pacific Islanders (OR = 0.63, 95% CI = 0.45—0.89), and Hispanic/Latino respondents (OR = 0.69, 95% CI = 0.53—0.89) had lower odds of leisure-time physical activity. On the neighborhood level, the percent of adults who reported they feel safe in their neighborhood was significant (<i>p</i> &lt; .001), but violence prevalence was not (<i>p</i> = 0.091).</p> Conclusions <p>These results can inform public health efforts to promote physical activity following the COVID-19 stay-at-home order.</p>