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Purpose of Review <p>The transcription factor and oncoprotein Ets-1 regulates the transcription of several target genes involved in several biological processes such as tumor progression. This activity of Ets-1 is mediated by its interaction with protein partners. The aim of this review is to summarize the interacting partners of Ets-1 and to provide an overview of their role in the regulation of Ets-1 transcriptional activity.</p> Recent Findings <p>A number of studies have shown that Ets-1 interacts with a large number of transcription factors, nuclear receptors, cofactors, and modifying enzymes that determine the final biological outcome. Most of these interactors activates Ets-1, while others repress it. This has improved our understanding of the role of Ets-1 in tumor progression.</p> Summary <p>The identification of novel Ets-1 interactors will be important to complete the understanding of its regulatory networks and may help to develop therapeutic strategies that target protein-protein interaction.</p>

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Ets-1 Protein Interactors in Transcriptional Activity Regulation

  • 期刊论文

  • 发表日期：

    2025年6月18日

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  • Souhaila Choul-li,
  • Marc Aumercier

摘要

Purpose of Review

The transcription factor and oncoprotein Ets-1 regulates the transcription of several target genes involved in several biological processes such as tumor progression. This activity of Ets-1 is mediated by its interaction with protein partners. The aim of this review is to summarize the interacting partners of Ets-1 and to provide an overview of their role in the regulation of Ets-1 transcriptional activity.

Recent Findings

A number of studies have shown that Ets-1 interacts with a large number of transcription factors, nuclear receptors, cofactors, and modifying enzymes that determine the final biological outcome. Most of these interactors activates Ets-1, while others repress it. This has improved our understanding of the role of Ets-1 in tumor progression.

Summary

The identification of novel Ets-1 interactors will be important to complete the understanding of its regulatory networks and may help to develop therapeutic strategies that target protein-protein interaction.