<p>The present study explored the self-care experiences of mothers of children with autism spectrum disorders (ASD) in the Accra Metropolis of Ghana. Mothers of children with autism have been found to experience significant challenges in the caregiving process due to the difficult behavior characteristics of their children, and this requires them to properly care for themselves to function well. The qualitative phenomenological research design guided the data collection and analysis involving in-depth interviews with 12 mothers of children with ASD. Using Braun and Clarke’s thematic analysis, four themes emerged including (1) caring experiences, (2) understanding of self-care, (3) self-care strategies, and (4) obstacles to self-care. Mothers expressed concerns about the difficult caring experiences and how their understanding of self-care helps alleviate their stress. Although mothers reported using some self-care strategies, they also indicated obstacles to self-care. Findings of this study indicate mothers’ interest in getting opportunities for self-care to assuage their stress and achieve satisfaction with the caregiving role. This warrants the design of intervention programs to improve self-care, reduce the distress of mothers, and improve the quality of care for their children with ASD.</p>