Scholarlink

Purpose of review <p>Organoid technology has become a powerful tool for studying tissue architecture, physiological processes and disease mechanisms. While research has largely focused on human and mouse models, expanding organoid technology to non-model species provides new opportunities in various disciplines. This review highlights the development of animal-derived organoids and their value in modeling species-specific traits, infections, and environmental factors.</p> Recent findings <p>Organoids from species like bats and other taxa offer insights into host-pathogen interactions, immune responses, and evolutionary biology, while reducing the need for live animal testing. Progress in non-model species organoid development is, however, hampered by challenges such as the need for species-specific growth media and lack of standardized protocols.</p> Summary <p>Despite these obstacles, non-model organoids offer ethical, scalable, and physiologically relevant alternatives to traditional in vitro or in vivo models. Advancing their development through common standards, better genomic data, and integration with more complex systems will be key to unlocking their full potential.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Diverse Organoid Models and their Utility in the One Health Framework

  • 期刊论文

  • 发表日期：

    2026年5月22日

查看全文
  • Sophie-Marie Aicher,
  • Hannah Mahoney,
  • Ansalna Ansari,
  • Kristof Jenik,
  • Sauhard Shrivastava,
  • Neeraj Dhar,
  • Samira Mubareka,
  • Arinjay Banerjee

摘要

Purpose of review

Organoid technology has become a powerful tool for studying tissue architecture, physiological processes and disease mechanisms. While research has largely focused on human and mouse models, expanding organoid technology to non-model species provides new opportunities in various disciplines. This review highlights the development of animal-derived organoids and their value in modeling species-specific traits, infections, and environmental factors.

Recent findings

Organoids from species like bats and other taxa offer insights into host-pathogen interactions, immune responses, and evolutionary biology, while reducing the need for live animal testing. Progress in non-model species organoid development is, however, hampered by challenges such as the need for species-specific growth media and lack of standardized protocols.

Summary

Despite these obstacles, non-model organoids offer ethical, scalable, and physiologically relevant alternatives to traditional in vitro or in vivo models. Advancing their development through common standards, better genomic data, and integration with more complex systems will be key to unlocking their full potential.