Purpose of Review <p>There is increasing evidence that several environmental exposures may pose a risk for depression, including maternal depression. We conducted a scoping review of epidemiological evidence regarding maternal exposure to environmental chemicals and perinatal depression.</p> Recent Findings <p>We searched PubMed, Embase, Web of Science, Dimensions, and Scopus, and summarized the findings from 27 articles that examined environmental chemical exposures and maternal depression. Studies of ambient air pollutants (<i>N</i> = 11) showed exposure to NO₂ and PM₁₀ to be most consistently associated with antenatal or postnatal depression. Studies of endocrine-disrupting chemicals, including phthalates (<i>n</i> = 6), per- and polyfluoroalkyl substances (PFAS, <i>n</i> = 6), polybrominated diphenyl ethers (PBDE, <i>n</i> = 3), organophosphate esters flame retardants (OPE, <i>n</i> = 2), and pesticides (<i>n</i> = 1), reported positive links with maternal depression, particularly from exposures to phthalates and PBDE. Studies of the individual and mixture of metals (<i>n</i> = 3) have reported mixed results.</p> Summary <p>Maternal exposures to certain airborne pollutants, and chemicals from contaminated household products and food sources, are associated with maternal depression. If these findings are confirmed, reducing environmental risks may represent a promising strategy for the primary prevention of maternal depression.</p>