Purpose of Review <p>Hymenoptera venom allergy (HVA) is a potentially life-threatening condition mainly caused by stings from bees and wasps, that may lead to systemic reactions and, thus, affect the quality of life of our patients. The purpose of this review is to provide an overview of the literature relating to venom allergy.</p> Recent Findings <p>Diagnosis relies on clinical history, skin testing, and specific IgE, with molecular diagnostics helping in species differentiation. Risk factors include age, male sex, high exposure, and mast cell disease. Local and systemic reactions vary in severity, with venom immunotherapy being the only available curative treatment, which improves both physical symptoms and quality of life. Accurate identification of the culprit insect is crucial for targeted treatment.</p> Summary <p>Life-threatening HVA can be a challenge for allergists. A continuous updating of knowledge on allergically relevant species and on their venoms and allergens is needed to find diagnostic procedures and treat the allergic population.</p>