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Objective <p>Intrinsic capacity (IC) is a person-centered comprehensive assessment framework that focuses on optimizing individuals’ functional ability and resilience to environmental challenges, defined as the sum of all physical and mental capacities of an individual. Based on cohort data from the CHARLS, this study investigated the associations of baseline IC and its dynamic transition patterns with the risk of incident diabetes in middle-aged and older adults, aiming to provide evidence for precise diabetes prevention and control.</p> Methods <p>Five waves of CHARLS data (2011–2020) were included, with 2011 as the baseline. IC transition patterns were assessed using 2011–2013 data, and participants were followed up to 2020 for incident diabetes. Cox proportional hazards regression was performed to evaluate these associations.</p> Results <p>15.6% of participants developed diabetes. Compared with the low IC group, moderate and high IC groups had an 18.8% and 26.7% lower risk of diabetes, respectively. Four IC patterns were identified: Improved IC, Stable IC Impairment, Declined IC, and Stable Non-IC Impairment. Compared with Stable Non-IC Impairment, the Improved IC (<i>HR</i> 1.272, 95% <i>CI</i>: 1.019,1.588) and Stable IC Impairment (<i>HR</i> 1.474, 95% <i>CI</i>: 1.167,1.863) groups had significantly higher risks, whereas the Declined IC group showed no significant association.</p> Conclusion <p>Baseline IC and its dynamic transition patterns are differentially associated with diabetes risk in middle-aged and older adults. IC should be integrated into diabetes prevention and control systems, with dynamic monitoring and individualized interventions to reduce disease risk.</p>

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Association between intrinsic capacity transitions and the risk of diabetes in middle-aged and older adults

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月5日

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  • Xiaoling Lin,
  • Shiyang Zhang,
  • Wenhui Zhu,
  • Jiewei Huang,
  • Xianghua Yuan

摘要

Objective

Intrinsic capacity (IC) is a person-centered comprehensive assessment framework that focuses on optimizing individuals’ functional ability and resilience to environmental challenges, defined as the sum of all physical and mental capacities of an individual. Based on cohort data from the CHARLS, this study investigated the associations of baseline IC and its dynamic transition patterns with the risk of incident diabetes in middle-aged and older adults, aiming to provide evidence for precise diabetes prevention and control.

Methods

Five waves of CHARLS data (2011–2020) were included, with 2011 as the baseline. IC transition patterns were assessed using 2011–2013 data, and participants were followed up to 2020 for incident diabetes. Cox proportional hazards regression was performed to evaluate these associations.

Results

15.6% of participants developed diabetes. Compared with the low IC group, moderate and high IC groups had an 18.8% and 26.7% lower risk of diabetes, respectively. Four IC patterns were identified: Improved IC, Stable IC Impairment, Declined IC, and Stable Non-IC Impairment. Compared with Stable Non-IC Impairment, the Improved IC (HR 1.272, 95% CI: 1.019,1.588) and Stable IC Impairment (HR 1.474, 95% CI: 1.167,1.863) groups had significantly higher risks, whereas the Declined IC group showed no significant association.

Conclusion

Baseline IC and its dynamic transition patterns are differentially associated with diabetes risk in middle-aged and older adults. IC should be integrated into diabetes prevention and control systems, with dynamic monitoring and individualized interventions to reduce disease risk.