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<p>Hyaluronic acid (HA) is a linear polysaccharide which occurs naturally as a constituent of synovial fluid. The HA concentration in the joint decreases inexorably during the progression of knee osteoarthritis (OA) and so, for nearly five decades, HA has been trialled and used in the treatment of knee OA. There are strong data from clinical trials, meta-analyses and umbrella reviews to support the use of intra-articular hyaluronic acid (IAHA) in the treatment of patients with knee OA, though not in patients with acute, active OA experiencing a flare. The majority of the literature suggests that IAHA has a positive safety profile despite a few meta-analyses suggesting an increased risk of serious adverse effects. Further qualitative analysis integrating patient preferences for multi-modal and/or non-surgical management is required in order to further explore these findings. IAHA has been combined with a number of additional agents, including mannitol, sorbitol, chondroitin sulphate, tranexamic acid, polynucleotides and hybrid IAHA formulations. These show variable performance beyond the baseline effect of their constituents. It is crucial to consider the patient’s preference when considering treatments for knee OA. Specific to IAHA, patients seek minimally invasive, lower-risk, and non-steroidal options with at least moderate efficacy and advantageous safety profiles.</p>

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Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月1日

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  • Nicholas Fuggle,
  • François Rannou,
  • Emmanuel Maheu,
  • Alberto Migliore,
  • Nasser Al-Daghri,
  • Majed Alokail,
  • Patrick Ammann,
  • Francis Berenbaum,
  • Angie Botto-van Bemden,
  • Maria Luisa Brandi,
  • Nansa Burlet,
  • Roland Chapurlat,
  • Cyrus Cooper,
  • Elaine Dennison,
  • Nicholas C Harvey,
  • Gun-il Im,
  • Andreas Kurth,
  • Radmila Matijevic,
  • Daniel Messina,
  • Jordi Monfort Faure,
  • Régis P. Radermecker,
  • Ralf Schmidmaier,
  • Stuart Silverman,
  • Julien Wegrzyn,
  • Leith Zakraoui,
  • René Rizzoli,
  • Jean-Yves Reginster,
  • Olivier Bruyère,
  • Ali Mobasheri

摘要

Hyaluronic acid (HA) is a linear polysaccharide which occurs naturally as a constituent of synovial fluid. The HA concentration in the joint decreases inexorably during the progression of knee osteoarthritis (OA) and so, for nearly five decades, HA has been trialled and used in the treatment of knee OA. There are strong data from clinical trials, meta-analyses and umbrella reviews to support the use of intra-articular hyaluronic acid (IAHA) in the treatment of patients with knee OA, though not in patients with acute, active OA experiencing a flare. The majority of the literature suggests that IAHA has a positive safety profile despite a few meta-analyses suggesting an increased risk of serious adverse effects. Further qualitative analysis integrating patient preferences for multi-modal and/or non-surgical management is required in order to further explore these findings. IAHA has been combined with a number of additional agents, including mannitol, sorbitol, chondroitin sulphate, tranexamic acid, polynucleotides and hybrid IAHA formulations. These show variable performance beyond the baseline effect of their constituents. It is crucial to consider the patient’s preference when considering treatments for knee OA. Specific to IAHA, patients seek minimally invasive, lower-risk, and non-steroidal options with at least moderate efficacy and advantageous safety profiles.