Background <p>Sarcopenia is a growing problem, especially in nursing care. It is therefore mandatory to integrate measures such as resistance training to maintain muscle strength into nursing care.</p> Aims <p>The aim of this study was to investigate the acceptance and feasibility of a novel training algorithm in a nursing home environment. Furthermore, the reliability of measurements for the diagnosis of sarcopenia was tested in the nursing home setting.</p> Methods <p>Twenty-eight nursing home residents took part in the study, which encompassed two pre- and two post-examinations and a four-week training intervention. The training sessions were documented with regard to acceptance and feasibility as well as training motivation and intensity.</p> Results <p>A combined acceptance and feasibility of at least 54% was shown, quantifying adherence of the residents to the training. The operational feasibility was 91% and the exercise performance feasibility of the residents was between 88% and 94.2%. All intraclass correlation coefficients showed at least a good reliability (all ≥ 0.84). Training motivation was higher when participants trained in a group (<i>p</i> = 0.007), but training intensity was greater when they trained individually (<i>p</i> &lt; 0.001).</p> Discussion <p>The main influencing factors for acceptance and feasibility were illness in general and a lack of motivation by the residents. Against the assumption, training was also possible during the weekends.</p> Conclusions <p>In conclusion, the study shows that our proposed training algorithm is acceptable and feasible in a nursing home environment. In future, the efficacy of the training needs to be shown.</p> Trial registration number <p>DRKS00030211; Date of registration: 2022-09-12.</p>