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Background <p>Dynapenia and obesity have been independently shown to be associated with an increased risk of all-cause mortality. However, the association between dynapenic obesity [defined by waist circumference (WC) or body mass index (BMI)] and all-cause mortality is not yet fully elucidated.</p> Methods <p>We systematically searched databases, including PubMed, Web of Science, and Scopus, to explore the relationship between dynapenic obesity and all-cause mortality up to February 2024. Pooled hazard ratios (HRs) for all-cause mortality were calculated for individuals with dynapenic abdominal obesity (DAO) and dynapenic obesity defined by BMI relative to a healthy reference group.</p> Results <p>Six studies examining DAO and six assessing dynapenic obesity defined by BMI were included. Individuals with DAO had a significantly higher risk of all-cause mortality compared to those without dynapenia and with normal WC. The pooled HR for DAO versus non-dynapenic, non-abdominal obese individuals was 1.73 (95% CI = 1.38–2.16), with substantial heterogeneity across studies (I2 = 77%, <i>p</i> &lt; 0.01). Similarly, individuals with dynapenic obesity, as defined by BMI, showed an elevated mortality risk compared to those with normal BMI, with an HR of 1.33 (95% CI = 1.16–1.53). High heterogeneity was observed across these studies (I2 = 76%, <i>p</i> &lt; 0.01).</p> Conclusion <p>This meta-analysis reveals a significant association between dynapenic obesity, whether defined by WC or BMI, with an increased risk of all-cause mortality. Further studies are needed to explore the underlying mechanisms driving this relationship.</p> Graphical Abstract <p></p>

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Dynapenic obesity and all-Cause mortality: A systematic review and Meta-analysis of prospective cohort studies

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月7日

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  • Amirabbas Nikkhah,
  • Farshad Sharifi,
  • Pouya Ebrahimi,
  • Marjan Rahimi,
  • Elaheh Karimi,
  • Amirhosein Kefayat,
  • Moloud Payab,
  • Bagher Larijani,
  • Mahbube Ebrahimpur

摘要

Background

Dynapenia and obesity have been independently shown to be associated with an increased risk of all-cause mortality. However, the association between dynapenic obesity [defined by waist circumference (WC) or body mass index (BMI)] and all-cause mortality is not yet fully elucidated.

Methods

We systematically searched databases, including PubMed, Web of Science, and Scopus, to explore the relationship between dynapenic obesity and all-cause mortality up to February 2024. Pooled hazard ratios (HRs) for all-cause mortality were calculated for individuals with dynapenic abdominal obesity (DAO) and dynapenic obesity defined by BMI relative to a healthy reference group.

Results

Six studies examining DAO and six assessing dynapenic obesity defined by BMI were included. Individuals with DAO had a significantly higher risk of all-cause mortality compared to those without dynapenia and with normal WC. The pooled HR for DAO versus non-dynapenic, non-abdominal obese individuals was 1.73 (95% CI = 1.38–2.16), with substantial heterogeneity across studies (I2 = 77%, p < 0.01). Similarly, individuals with dynapenic obesity, as defined by BMI, showed an elevated mortality risk compared to those with normal BMI, with an HR of 1.33 (95% CI = 1.16–1.53). High heterogeneity was observed across these studies (I2 = 76%, p < 0.01).

Conclusion

This meta-analysis reveals a significant association between dynapenic obesity, whether defined by WC or BMI, with an increased risk of all-cause mortality. Further studies are needed to explore the underlying mechanisms driving this relationship.

Graphical Abstract