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Purpose <p>Obesity is a complex heterogeneous disease often associated with dysfunctional eating behavior patterns. Oxytocin (OT) is a neurohormone involved in the regulation of energy metabolism and eating behavior. The aim of the present study was to evaluate in a population of patients with obesity circulating levels of OT and dysfunctional eating behaviors in relation to anthropometric, hormonal and metabolic parameters.</p> Methods <p>A prospective, observational, single-center study was conducted at the Center of High Specialization for the Care of Obesity of Sapienza University of Rome. Adult subjects with body mass index (BMI) ≥ 30&#xa0;kg/m2 were recruited. Body impedance assessment (BIA), biochemical and hormonal parameters, plasma OT concentration analysis and the Eating Behaviors Assessment for Obesity (EBA-O) questionnaire were evaluated.</p> Results <p>A total of 21 patients, 16 females and 5 males, with a mean age of 45.7 ± 15.1&#xa0;years, mean BMI of 40.89 ± 8.02&#xa0;kg/m<sup>2</sup> and plasma OT concentration of 1365.61 ± 438.03&#xa0;pg/mL were recruited. The dysfunctional eating behavior traits investigated by the EBA-O appear significantly associated with metabolic derangements. In particular, night eating is associated with alterations in lipid metabolism (<i>p</i> &lt; 0.01). Circulating OT correlates positively with BMI (<i>r</i> = 0,43; <i>p</i> &lt; 0.05), and Hepatic Steatosis Index (HIS) (<i>r</i> = 0.46; <i>p</i> &lt; 0.05), while its role in subjects with obesity and alterations in glucose metabolism is less clear. Interestingly, circulating OT levels &lt; 1312.55&#xa0;pg/mL may be predictive of food addiction (100% sensitivity; 62.5% specificity).</p> Conclusions <p>Despite the need for larger studies to confirm their validity, the clinical utility of the EBA-O and circulating OT in identifying dysfunctional eating behaviors appears promising.</p>

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Eating behavior patterns, metabolic parameters and circulating oxytocin levels in patients with obesity: an exploratory study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月17日

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  • Elena Colonnello,
  • Flavia Libotte,
  • Davide Masi,
  • Mariaignazia Curreli,
  • Chandra Massetti,
  • Orietta Gandini,
  • Elena Gangitano,
  • Mikiko Watanabe,
  • Stefania Mariani,
  • Lucio Gnessi,
  • Carla Lubrano

摘要

Purpose

Obesity is a complex heterogeneous disease often associated with dysfunctional eating behavior patterns. Oxytocin (OT) is a neurohormone involved in the regulation of energy metabolism and eating behavior. The aim of the present study was to evaluate in a population of patients with obesity circulating levels of OT and dysfunctional eating behaviors in relation to anthropometric, hormonal and metabolic parameters.

Methods

A prospective, observational, single-center study was conducted at the Center of High Specialization for the Care of Obesity of Sapienza University of Rome. Adult subjects with body mass index (BMI) ≥ 30 kg/m2 were recruited. Body impedance assessment (BIA), biochemical and hormonal parameters, plasma OT concentration analysis and the Eating Behaviors Assessment for Obesity (EBA-O) questionnaire were evaluated.

Results

A total of 21 patients, 16 females and 5 males, with a mean age of 45.7 ± 15.1 years, mean BMI of 40.89 ± 8.02 kg/m2 and plasma OT concentration of 1365.61 ± 438.03 pg/mL were recruited. The dysfunctional eating behavior traits investigated by the EBA-O appear significantly associated with metabolic derangements. In particular, night eating is associated with alterations in lipid metabolism (p < 0.01). Circulating OT correlates positively with BMI (r = 0,43; p < 0.05), and Hepatic Steatosis Index (HIS) (r = 0.46; p < 0.05), while its role in subjects with obesity and alterations in glucose metabolism is less clear. Interestingly, circulating OT levels < 1312.55 pg/mL may be predictive of food addiction (100% sensitivity; 62.5% specificity).

Conclusions

Despite the need for larger studies to confirm their validity, the clinical utility of the EBA-O and circulating OT in identifying dysfunctional eating behaviors appears promising.