<p>The purpose of this study is to expand the discussion of entrepreneurship and start-up in crises by analyzing the impact of entrepreneurship education and accessibility to entrepreneurship education as a preemptive approach based on human capital theory. This study differentiates itself from previous research by combining the discussion on the effectiveness of entrepreneurship education with the concept of accessibility. To analyze whether entrepreneurship education and accessibility to education can mitigate the negative impact of the COVID-19 pandemic on the satisfaction of middle-aged entrepreneurs, a moderated moderating effect model was set up. Survey data were collected from 323 middle-aged and early-stage entrepreneurs residing in Seoul, Korea. This study confirms that although the COVID-19 pandemic had a negative impact on middle-aged entrepreneurs, those who had easy access to entrepreneurship education during the start-up preparation were able to mitigate this impact through their participation in entrepreneurship education. The findings show a significant correlation between entrepreneurship education accessibility and entrepreneurial satisfaction, indicating that accessibility may influence resilience against crises. This study broadens the perspective on entrepreneurship education from the human capital theory, proposing that the notion of accessibility to entrepreneurship education could play a significant role depending on the entrepreneur. Additionally, it has been verified that proactively accumulated human capital enhances crisis-coping capacity.</p>