Scholarlink

Purpose of Review <p>Burning Mouth Syndrome (BMS) is a multifactorial condition characterized by persistent oral burning in the absence of visible clinical abnormalities. This systematic review aimed to evaluate the prevalence, allergen spectrum, and clinical relevance of hypersensitivity to dental materials in patients with BMS, and to assess symptom outcomes following allergen removal or avoidance.</p> Recent Findings <p>A systematic search of PubMed, ScienceDirect, and the Cochrane Library identified 27 eligible studies from 357 identified records, consisting primarily of observational studies, case series, and case reports. Common allergens included nickel, gold, mercury, palladium, cobalt, and acrylate-based materials. Patch test positivity rates ranged from approximately 13% to over 60%, reflecting substantial heterogeneity across study populations and testing protocols. Qualitative JBI-based critical appraisal indicated that most studies showed some concern or great concern for bias within design, largely because of retrospective designs, small samples, inconsistent diagnostic criteria, and incomplete outcome reporting.</p> Summary <p>The available evidence suggests an association between hypersensitivity to dental materials and BMS-like symptoms in a subset of patients, particularly when positive patch-test findings are accompanied by plausible intraoral exposure and symptom improvement after material avoidance or replacement. These findings should be interpreted cautiously because the evidence is primarily observational and heterogeneous. Patch testing may serve as a useful adjunctive diagnostic tool in selected patients, especially when secondary causes are suspected, but hypersensitivity should be considered within a broader multifactorial context. Further well-designed prospective studies with standardized diagnostic, relevance, and outcome criteria are required.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association Between Burning Mouth Syndrome and Dental Material Hypersensitivity: A Systematic Review of Patch Test Findings and Clinical Outcomes

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月8日

查看全文
  • Ahmad Bittar,
  • Tan Fırat Eyüboğlu,
  • Fabienne Andrina Bosshard,
  • Bernd Stadlinger,
  • Mutlu Özcan

摘要

Purpose of Review

Burning Mouth Syndrome (BMS) is a multifactorial condition characterized by persistent oral burning in the absence of visible clinical abnormalities. This systematic review aimed to evaluate the prevalence, allergen spectrum, and clinical relevance of hypersensitivity to dental materials in patients with BMS, and to assess symptom outcomes following allergen removal or avoidance.

Recent Findings

A systematic search of PubMed, ScienceDirect, and the Cochrane Library identified 27 eligible studies from 357 identified records, consisting primarily of observational studies, case series, and case reports. Common allergens included nickel, gold, mercury, palladium, cobalt, and acrylate-based materials. Patch test positivity rates ranged from approximately 13% to over 60%, reflecting substantial heterogeneity across study populations and testing protocols. Qualitative JBI-based critical appraisal indicated that most studies showed some concern or great concern for bias within design, largely because of retrospective designs, small samples, inconsistent diagnostic criteria, and incomplete outcome reporting.

Summary

The available evidence suggests an association between hypersensitivity to dental materials and BMS-like symptoms in a subset of patients, particularly when positive patch-test findings are accompanied by plausible intraoral exposure and symptom improvement after material avoidance or replacement. These findings should be interpreted cautiously because the evidence is primarily observational and heterogeneous. Patch testing may serve as a useful adjunctive diagnostic tool in selected patients, especially when secondary causes are suspected, but hypersensitivity should be considered within a broader multifactorial context. Further well-designed prospective studies with standardized diagnostic, relevance, and outcome criteria are required.