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Purpose of Review <p>This review aims to investigate whether autosomal dominant polycystic kidney disease (ADPKD) is associated with oral dysbiosis and to summarize the mechanistic overlaps suggested by the current literature. Given the limited direct clinical data, this review focuses on evaluating potential pathways linking changes in the oral microbiome to ADPKD.</p> Recent Findings <p>Recent research has revealed notable alterations in the oral microbiome associated with chronic kidney disease, highlighting the roles of inflammation and renin-angiotensin-aldosterone system activation in both periodontal disease and kidney dysfunction. Although ADPKD is characterized by increased cytokines, oxidative stress, and dysbiosis in other organ systems, no studies have specifically examined oral microbial changes in ADPKD.</p> Summary <p>The review suggests that a connection between ADPKD and oral dysbiosis is biologically plausible but remains hypothetical because no study has yet directly examined oral microbial or periodontal changes in ADPKD. Future ADPKD specific studies should evaluate oral microbiome profiles, periodontal status, and inflammatory markers to clarify whether such a relationship exists.</p>

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Interrelationship Between Autosomal Dominant Polycystic Kidney Disease and Oral Dysbiosis: Mechanisms and Implications

  • 期刊论文

  • 发表日期：

    2026年6月3日

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  • Eda Aslanlı,
  • Zeynep Akcalı,
  • Aliye Akcalı

摘要

Purpose of Review

This review aims to investigate whether autosomal dominant polycystic kidney disease (ADPKD) is associated with oral dysbiosis and to summarize the mechanistic overlaps suggested by the current literature. Given the limited direct clinical data, this review focuses on evaluating potential pathways linking changes in the oral microbiome to ADPKD.

Recent Findings

Recent research has revealed notable alterations in the oral microbiome associated with chronic kidney disease, highlighting the roles of inflammation and renin-angiotensin-aldosterone system activation in both periodontal disease and kidney dysfunction. Although ADPKD is characterized by increased cytokines, oxidative stress, and dysbiosis in other organ systems, no studies have specifically examined oral microbial changes in ADPKD.

Summary

The review suggests that a connection between ADPKD and oral dysbiosis is biologically plausible but remains hypothetical because no study has yet directly examined oral microbial or periodontal changes in ADPKD. Future ADPKD specific studies should evaluate oral microbiome profiles, periodontal status, and inflammatory markers to clarify whether such a relationship exists.