Purpose of Review <p>Several studies linking periodontitis and ocular diseases have been conducted over recent years, but the full extent of this relationship has not yet been established. Careful analysis of available data is required to explore the nature of the association and to develop an understanding of the possible biological mechanisms connecting periodontitis with ocular diseases. Accordingly, this review aimed to investigate reported relationships and explore biological mechanistic links between periodontitis and ocular diseases. A comprehensive literature search in PubMed, Scopus, and Google Scholar, yielded 231 papers of which 26 met the eligibility criteria used for evidence synthesis.</p> Recent Findings <p>Periodontitis represents a source of elevated inflammatory cytokines and systemically translocated oral pathobionts in the circulation, which may negatively affect distant organs and systemic disease states, potentially including ocular diseases.</p> Summary <p>Periodontitis is likely to be associated with a significantly higher prevalence of multiple ocular diseases. Current evidence is insufficient to establish a causal link between periodontitis and ocular diseases, but it provides a foundation for high-quality, large-scale, multi-center prospective cohort studies and clinical trials to further explore the underlying biological mechanisms.</p>