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Purpose of Review <p>To compile recent advances in scaffold-guided periodontal regeneration (SGPR) enabled by 3D printing, focusing on innovations in materials, multiphasic/anisotropic design, image-guided personalization, and the spatiotemporal delivery of therapeutic cues.</p> Recent Findings <p>Composite scaffold systems, extracellular matrix (ECM)-mimetic hydrogels, and ion-releasing ceramics (e.g., Mg/Sr/Ca-phosphates, bioactive glass, among others) enhance osteogenesis, periodontal ligament (PDL) formation, and angiogenesis. Melt electrowriting, extrusion, and inkjet printing enable the creation of patient-specific, multiphasic and anisotropic scaffolds that mimic cementum-PDL-bone interfaces. Controlled release of ions, growth factors, genes, and antimicrobials modulate immunity and microenvironments. Emerging directions include in situ and 4D bioprinting, immuno-instructive and prevascularized constructs, and CAD models derived from clinical imaging, which are essential for manufacturing personalized scaffolds and grafts.</p> Summary <p> 3D printing is advancing SGPR toward functional, personalized therapies; however, its translation depends on reliable vascularization, immune modulation, long-term mechanics, scalable manufacturing, and clear regulatory and safety pathways. Standardized workflows, hybrid/4D printing, machine-learning-guided design, and rigorous clinical studies are essential to accelerate clinical adoption.</p>

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Advances in 3D Printed Scaffolds for Periodontal Regeneration

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月27日

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  • Arwa Daghrery,
  • Igor Paulino Mendes Soares,
  • Alexandre H. dos Reis‑Prado,
  • Isaac J. de Souza Araújo,
  • Renan Dal-Fabbro,
  • Marco C. Bottino

摘要

Purpose of Review

To compile recent advances in scaffold-guided periodontal regeneration (SGPR) enabled by 3D printing, focusing on innovations in materials, multiphasic/anisotropic design, image-guided personalization, and the spatiotemporal delivery of therapeutic cues.

Recent Findings

Composite scaffold systems, extracellular matrix (ECM)-mimetic hydrogels, and ion-releasing ceramics (e.g., Mg/Sr/Ca-phosphates, bioactive glass, among others) enhance osteogenesis, periodontal ligament (PDL) formation, and angiogenesis. Melt electrowriting, extrusion, and inkjet printing enable the creation of patient-specific, multiphasic and anisotropic scaffolds that mimic cementum-PDL-bone interfaces. Controlled release of ions, growth factors, genes, and antimicrobials modulate immunity and microenvironments. Emerging directions include in situ and 4D bioprinting, immuno-instructive and prevascularized constructs, and CAD models derived from clinical imaging, which are essential for manufacturing personalized scaffolds and grafts.

Summary

3D printing is advancing SGPR toward functional, personalized therapies; however, its translation depends on reliable vascularization, immune modulation, long-term mechanics, scalable manufacturing, and clear regulatory and safety pathways. Standardized workflows, hybrid/4D printing, machine-learning-guided design, and rigorous clinical studies are essential to accelerate clinical adoption.