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Purpose of Review <p>This review aims to summarise the current epidemiological evidence for associations between periodontitis and chronic kidney disease (CKD), and to explore the underlying biological mechanisms.&#xa0;</p> Recent Findings <p>CKD is strongly associated with periodontitis in both cross-sectional and longitudinal studies, with 2.5 higher odds of having periodontitis in the presence of CKD and 2-times higher likelihood of developing CKD in the presence of periodontitis. Patients with CKD and periodontitis have a hazard ratio of 3.1 for progression of CKD when pockets are greater than 4.5mm compared to without. The biological mechanisms underlying this relationship include common risk factors of smoking and diabetes, the systemic inflammatory burden posed by periodontitis, and the detrimental effect of periodontal pathogens on renal tissues.&#xa0;</p> Summary <p>Evidence supports a bidirectional relationship between periodontitis and CKD whereby periodontal care may represent an important and novel management strategy for individuals with CKD. </p>

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Epidemiology and Biological Mechanisms Linking Periodontitis with Chronic Kidney Disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月1日

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  • Philip Eburne,
  • Iain Chapple,
  • Praveen Sharma

摘要

Purpose of Review

This review aims to summarise the current epidemiological evidence for associations between periodontitis and chronic kidney disease (CKD), and to explore the underlying biological mechanisms. 

Recent Findings

CKD is strongly associated with periodontitis in both cross-sectional and longitudinal studies, with 2.5 higher odds of having periodontitis in the presence of CKD and 2-times higher likelihood of developing CKD in the presence of periodontitis. Patients with CKD and periodontitis have a hazard ratio of 3.1 for progression of CKD when pockets are greater than 4.5mm compared to without. The biological mechanisms underlying this relationship include common risk factors of smoking and diabetes, the systemic inflammatory burden posed by periodontitis, and the detrimental effect of periodontal pathogens on renal tissues. 

Summary

Evidence supports a bidirectional relationship between periodontitis and CKD whereby periodontal care may represent an important and novel management strategy for individuals with CKD.