Purpose of Review <p>This review aims to explore recent advances in regenerative dentistry through the lens of functionality-driven biomaterials. It emphasizes the classification of these materials based on their biological roles and therapeutic mechanisms, with a translational focus on clinical applicability.</p> Recent Findings <p>The field has evolved from inert materials to bioactive, bioinstructive, and multifunctional platforms that modulate cell behavior, immune responses, and tissue regeneration. Functional materials such as peptide-modified hydrogels, ion-releasing ceramics, and 3D-printed scaffolds are now widely investigated across regenerative endodontics, periodontology, implantology, craniofacial reconstruction, and TMJ repair. Emerging technologies like smart polymers and nanofabrication have enhanced spatial control, responsiveness, and integration potential.</p> Summary <p>Functionality-guided biomaterial design marks a paradigm shift in dental regeneration. By integrating advanced fabrication with biologically informed strategies, these materials enable predictable, personalized, and outcome-oriented therapies, addressing unmet clinical needs in restorative and surgical dentistry.</p>