Purpose of Review <p>A psychoactive substance is any substance that, introduced into the body by any route of administration, produces an alteration in the functioning of the individual's central nervous system, modifying consciousness, mood or thought processes. Due to this, its consumption has been associated with the development of oral diseases. The purpose of this review was to determine the association between the consumption of psychoactive substances and periodontitis.</p> Recent findings <p>A systematic review with meta-analysis was carried out following the recommendations of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and The Cochrane Collaboration. Case–control, cohort and cross-sectional studies were considered. The primary outcome of interest was the frequency of periodontitis in each group. Risk of bias analysis of the studies and meta-analysis was carried out. Six studies were included in the qualitative and quantitative analysis. In 4 studies, the relative risk (RR) and odds ratio (OR) reported indicated a significant association between the consumption of psychoactive substances and periodontitis. The use of psychoactive substances was moderately associated with periodontitis (OR 2.66; 95% CI 1.86–3.81). However, when the effect of psychoactive substances on probing depth (PD) and periodontal attachment level (PAL) was analyzed, it was clinically insignificant.</p> Summary <p>The use of psychoactive substances is moderately and significantly associated with periodontitis, according to low-quality evidence.</p>