Purpose of Review <p>This review explores the efficacy of therapeutic plants in the therapy of oral and breast cancers, focusing on their action mechanisms like cell cycle arrest, induction of apoptosis, inhibition of metastasis, and alteration of main signalling mechanisms.</p> Recent findings <p>Oral and breast cancers pose significant health risks, and cancer remains a significant cause of mortality across the globe. Although conventional therapies are effective, they are often associated with severe adverse effects. Recently, many medicinal plants have acquired interest as potential alternative or complementary therapeutic agents due to the existence of bioactive constituents, which possess anti-inflammatory, anticancer, and antioxidant potential.</p> Conclusion <p>Phytoconstituents such as curcumin, resveratrol, quercetin, epigallocatechin gallate (EGCG), and berberine combat cancer cells through diverse mechanisms such as G0/G1 phase arrest, anti-microtubule and anti-mitotic activity, macrophage activation, inhibition of cancer cell progression through multiple signalling pathways, direct cytotoxicity, and anti-angiogenesis. Exploring these botanical sources and their metabolites may pave the way for the development of future cancer therapeutics.</p> Graphical Abstract <p>Graphical abstract Phytocompounds and its mechanisms of action, therapeutic effects against cancer</p> <p></p>