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Purpose of Review <p>Diabetic Kidney disease (DKD), a microvascular complication of diabetes, is the leading cause of end-stage renal disease (ESRD). In developing countries like India, DKD contributes significantly to cardiovascular morbidity and mortality. This review highlights the current strategies in preventing and managing DKD.</p> Recent Findings <p>The pathophysiology of DKD is multifactorial, involving hemodynamic, metabolic and inflammatory mechanisms driven primarily by chronic hyperglycemia, hypertension and dyslipidemia. The Southern part of India exhibits a higher prevalence of diabetes compared to northern and northeastern states due to growing diabetes prevalence and a sedentary lifestyle. An increased risk of impaired kidney function is observed in people with type 2 diabetes. The problem with managing DKD is that it often goes unnoticed in its early stages due to inadequate routine screening and patient unawareness.</p> Summary <p>The economic burden of DKD is significantly higher in developing countries like India. Hence, considering the pathogenesis of DKD, effective screening, preventive measures, and a multidisciplinary approach involving general physicians, diabetologists, dietitians, and nephrologists can be implemented to arrest disease progression.</p>

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Prevention of Diabetic Kidney Disease: the Chennai Experience

  • 期刊论文

  • 发表日期：

    2026年4月22日

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  • Vijay Viswanathan,
  • Reshma Mirshad,
  • Sivashankari Selva Elavarasan

摘要

Purpose of Review

Diabetic Kidney disease (DKD), a microvascular complication of diabetes, is the leading cause of end-stage renal disease (ESRD). In developing countries like India, DKD contributes significantly to cardiovascular morbidity and mortality. This review highlights the current strategies in preventing and managing DKD.

Recent Findings

The pathophysiology of DKD is multifactorial, involving hemodynamic, metabolic and inflammatory mechanisms driven primarily by chronic hyperglycemia, hypertension and dyslipidemia. The Southern part of India exhibits a higher prevalence of diabetes compared to northern and northeastern states due to growing diabetes prevalence and a sedentary lifestyle. An increased risk of impaired kidney function is observed in people with type 2 diabetes. The problem with managing DKD is that it often goes unnoticed in its early stages due to inadequate routine screening and patient unawareness.

Summary

The economic burden of DKD is significantly higher in developing countries like India. Hence, considering the pathogenesis of DKD, effective screening, preventive measures, and a multidisciplinary approach involving general physicians, diabetologists, dietitians, and nephrologists can be implemented to arrest disease progression.