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Introduction <p>Brain cancer poses significant challenges, largely due to the blood-brain barrier (BBB) impeding effective drug delivery. Traditional treatments often fall short, highlighting the need for innovative solutions. ZnO nanoparticles offer promise due to their ability to mitigate oxidative stress and potential to cross the BBB.</p> Objective <p>This review aims to explore how ZnO nanoparticles can revolutionize brain cancer management by addressing current treatment limitations and enhancing diagnostic and therapeutic strategies.</p> Methods <p>We conducted a comprehensive review of literature on ZnO nanoparticles, focusing on their properties relevant to neurological applications, including their interaction with reactive oxygen species, surface modification, and roles in drug delivery and imaging, particularly their ability to cross the BBB.</p> Results <p>ZnO nanoparticles show great potential. Their capacity to reduce oxidative stress and undergo surface functionalization makes them versatile. Crucially, their ability to bypass the BBB allows for direct and efficient delivery of chemotherapeutic agents to brain tumors, improving treatment efficacy. Furthermore, engineered ZnO nanoparticles can facilitate fluorescence-based imaging for precise tumor detection, guiding surgical interventions.</p> Conclusion <p>ZnO nanoparticles offer a transformative approach to brain cancer. By integrating advanced drug delivery with sophisticated imaging, these nanomaterials provide a multifunctional platform to overcome significant treatment hurdles, paving the way for more targeted and effective outcomes.</p>

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Emerging Areas of Application of Nano ZnO in Combating Brain Disorders

  • 期刊论文

  • 发表日期：

    2025年5月27日

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  • Moumita Sil,
  • Ankita Dey,
  • Rakesh Ghosh,
  • Arunava Goswami,
  • Shauryabrota Dalui,
  • Ishita Chatterjee,
  • Debasmita Bhattacharya,
  • Dibyajit Lahiri,
  • Moupriya Nag

摘要

Introduction

Brain cancer poses significant challenges, largely due to the blood-brain barrier (BBB) impeding effective drug delivery. Traditional treatments often fall short, highlighting the need for innovative solutions. ZnO nanoparticles offer promise due to their ability to mitigate oxidative stress and potential to cross the BBB.

Objective

This review aims to explore how ZnO nanoparticles can revolutionize brain cancer management by addressing current treatment limitations and enhancing diagnostic and therapeutic strategies.

Methods

We conducted a comprehensive review of literature on ZnO nanoparticles, focusing on their properties relevant to neurological applications, including their interaction with reactive oxygen species, surface modification, and roles in drug delivery and imaging, particularly their ability to cross the BBB.

Results

ZnO nanoparticles show great potential. Their capacity to reduce oxidative stress and undergo surface functionalization makes them versatile. Crucially, their ability to bypass the BBB allows for direct and efficient delivery of chemotherapeutic agents to brain tumors, improving treatment efficacy. Furthermore, engineered ZnO nanoparticles can facilitate fluorescence-based imaging for precise tumor detection, guiding surgical interventions.

Conclusion

ZnO nanoparticles offer a transformative approach to brain cancer. By integrating advanced drug delivery with sophisticated imaging, these nanomaterials provide a multifunctional platform to overcome significant treatment hurdles, paving the way for more targeted and effective outcomes.