Purpose <p>Peripheral nerve ultrasound in the pain medicine clinic remains largely non-standardized. The purpose of this technical note is to propose a structured point-of-care ultrasound protocol for systematic peripheral nerve evaluation in the interventional pain medicine setting.</p> Methods <p>The Peripheral Nerve Assessment Protocol (PNAP) was developed based on the existing peripheral nerve ultrasound literature, established point-of-care ultrasound models, and clinical experience in interventional pain medicine. The protocol targets 10 nerves across four anatomical regions using a four-step assessment sequence: static survey, dynamic provocation, Doppler interrogation, and contralateral comparison.</p> Results <p>Sonographic diagnostic criteria and a three-tier clinical decision framework are presented to guide same-visit treatment planning. The protocol integrates diagnostic assessment with procedural decision-making within a single clinical encounter.</p> Conclusion <p>The PNAP provides a reproducible methodology for peripheral nerve assessment in the interventional pain medicine clinic that may serve as a foundation for future validation studies.</p>