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Purpose <p>Epidermoid cysts and dermatofibromas may resemble malignant lesions, requiring accurate non-invasive differentiation. Our objective was to assess dermoscopy-guided high-frequency ultrasound (DG-HFUS) in distinguishing these lesions.</p> Methods <p>Nine lesions (four epidermoid cysts, five dermatofibromas) were examined using DG-HFUS with a 33&#xa0;MHz linear probe in B-mode. The dermoscopic modality guided probe placement. For each lesion, a minimum of 10 consecutive frames were acquired to ensure measurement reproducibility. Lesions were evaluated based on predetermined characteristics.</p> Results <p>Epidermoid cysts presented as well-circumscribed, oval lesions located in the dermis or dermal–subcutaneous border, with depths of 1.4–8.7&#xa0;mm. All showed mixed echogenicity with hyperechoic foci and bands. Dermatofibromas were smaller (2.4–3.5&#xa0;mm), within the dermis, hypoechoic with scattered hyperechoic areas, poorly defined margins, and 3–5 hypoechoic bands extending into surrounding structures.</p> Conclusion <p>DG-HFUS reliably correlated dermoscopic and sonographic features, enhancing non-invasive diagnosis of benign cutaneous lesions.</p>

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Characterization of dermatofibromas and epidermoid cysts using dermoscopy-guided high-frequency ultrasound imaging

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月27日

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  • P. Hamilton-Meikle,
  • M. Boostani,
  • N. Kiss,
  • G. Pellacani,
  • P. Holló,
  • N. Wikonkál,
  • S. Bozsányi,
  • A. Bánvölgy,
  • C. Cantisani

摘要

Purpose

Epidermoid cysts and dermatofibromas may resemble malignant lesions, requiring accurate non-invasive differentiation. Our objective was to assess dermoscopy-guided high-frequency ultrasound (DG-HFUS) in distinguishing these lesions.

Methods

Nine lesions (four epidermoid cysts, five dermatofibromas) were examined using DG-HFUS with a 33 MHz linear probe in B-mode. The dermoscopic modality guided probe placement. For each lesion, a minimum of 10 consecutive frames were acquired to ensure measurement reproducibility. Lesions were evaluated based on predetermined characteristics.

Results

Epidermoid cysts presented as well-circumscribed, oval lesions located in the dermis or dermal–subcutaneous border, with depths of 1.4–8.7 mm. All showed mixed echogenicity with hyperechoic foci and bands. Dermatofibromas were smaller (2.4–3.5 mm), within the dermis, hypoechoic with scattered hyperechoic areas, poorly defined margins, and 3–5 hypoechoic bands extending into surrounding structures.

Conclusion

DG-HFUS reliably correlated dermoscopic and sonographic features, enhancing non-invasive diagnosis of benign cutaneous lesions.