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Objectives <p>To characterize the contrast-enhanced ultrasound (CEUS) features of collecting duct carcinoma (CDC) with quantitative hemodynamic analysis.</p> Methods <p>A 28-year-old male with painless hematuria underwent CEUS (SonoVue<sup>®</sup>; MI = 0.07). Time-intensity curve (TIC) analysis was performed using Contrast Dynamics software.</p> Results <p>CEUS revealed: (1) Heterogeneous arterial enhancement (10&#xa0;s): Central hyperenhancement (peak SI 37.5%) with peripheral hypoenhancement. (2) Aggressive kinetics: TTP 30&#xa0;s, wash-out onset 35&#xa0;s. (3)Absent pseudocapsule sign. Pathology confirmed CDC (Vimentin + /34βE12 + /CK7-/CD10-).</p> Conclusion <p>This first comprehensive CEUS analysis of CDC demonstrates its unique microvascular phenotype-characterized by abnormal perfusion kinetics and absent pseudocapsule sign correlating with histologic aggressiveness. CEUS enhances CDC diagnosis when combined with immunohistochemistry.</p> Advances in knowledge <p>This study provides the first quantitative CEUS hemodynamic profile of CDC, identifying a diagnostic triad of heterogeneous enhancement, absent pseudocapsule, and "fast-in-fast-out" kinetics correlating with histologic aggressiveness. We demonstrate that integrating CEUS microvascular phenotyping with immunohistochemistry enhances diagnostic precision for this rare malignancy.</p>

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Contrast-enhanced ultrasound of renal collecting duct carcinoma: first report of quantitative microvascular characterization with pathologic correlation

  • 期刊论文

  • 发表日期：

    2026年2月23日

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  • Xueyan Wang,
  • Xiangmin Shen,
  • Chengcheng Niu,
  • Yan Luo,
  • Qinghai Peng,
  • Kui Tang

摘要

Objectives

To characterize the contrast-enhanced ultrasound (CEUS) features of collecting duct carcinoma (CDC) with quantitative hemodynamic analysis.

Methods

A 28-year-old male with painless hematuria underwent CEUS (SonoVue®; MI = 0.07). Time-intensity curve (TIC) analysis was performed using Contrast Dynamics software.

Results

CEUS revealed: (1) Heterogeneous arterial enhancement (10 s): Central hyperenhancement (peak SI 37.5%) with peripheral hypoenhancement. (2) Aggressive kinetics: TTP 30 s, wash-out onset 35 s. (3)Absent pseudocapsule sign. Pathology confirmed CDC (Vimentin + /34βE12 + /CK7-/CD10-).

Conclusion

This first comprehensive CEUS analysis of CDC demonstrates its unique microvascular phenotype-characterized by abnormal perfusion kinetics and absent pseudocapsule sign correlating with histologic aggressiveness. CEUS enhances CDC diagnosis when combined with immunohistochemistry.

Advances in knowledge

This study provides the first quantitative CEUS hemodynamic profile of CDC, identifying a diagnostic triad of heterogeneous enhancement, absent pseudocapsule, and "fast-in-fast-out" kinetics correlating with histologic aggressiveness. We demonstrate that integrating CEUS microvascular phenotyping with immunohistochemistry enhances diagnostic precision for this rare malignancy.