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<p>IgG4-related submandibular gland inflammation (IgG4-RSGI) is an immunologically mediated condition characterized by chronic fibroinflammatory lesions and elevated serum IgG4 levels. It often lacks specific clinical and imaging features, leading to misdiagnosis.We present a case of IgG4-RSGI to enhance clinical recognition and diagnostic accuracy. A patient presented with a four-month history of progressive bilateral submandibular gland enlargement. Ultrasonography revealed bilateral submandibular gland enlargement with heterogeneous internal echoes, a "mesh-like" pattern, and nodular hypoechoic areas. Color Doppler flow imaging (CDFI) showed increased vascularity. Ultrasound-guided biopsy confirmed the diagnosis, establishing ultrasound as a valuable initial diagnostic tool in the clinical assessment of IgG4-RSGI.</p>

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Ultrasonographic features and clinical management of IgG4-related submandibular gland inflammation: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月29日

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  • Wenhui Zhang,
  • Nan Pang,
  • Xu Wang,
  • Peng Fang,
  • Youjun Wang,
  • Ruixue Lu

摘要

IgG4-related submandibular gland inflammation (IgG4-RSGI) is an immunologically mediated condition characterized by chronic fibroinflammatory lesions and elevated serum IgG4 levels. It often lacks specific clinical and imaging features, leading to misdiagnosis.We present a case of IgG4-RSGI to enhance clinical recognition and diagnostic accuracy. A patient presented with a four-month history of progressive bilateral submandibular gland enlargement. Ultrasonography revealed bilateral submandibular gland enlargement with heterogeneous internal echoes, a "mesh-like" pattern, and nodular hypoechoic areas. Color Doppler flow imaging (CDFI) showed increased vascularity. Ultrasound-guided biopsy confirmed the diagnosis, establishing ultrasound as a valuable initial diagnostic tool in the clinical assessment of IgG4-RSGI.