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Purpose of Review <p>Understanding the attitudes and perceptions that healthcare workers (HCWs) hold towards xenotransplantation is necessary to ensure ongoing support in research and clinical settings. To date, there have been no survey studies on HCWs who participated in solid-organ xenotransplantation research, in either the decedent-model or a living patient.</p> Recent Findings <p>Two anonymous surveys were distributed to healthcare workers involved in the clinical management and coordination of pig-to-human xenokidney and xenoheart studies in brain-dead human decedents at a single institution. In total, 58 respondents were included, two-thirds of which exclusively provided direct medical care to the decedent while one-third exclusively provided operational or research support. Results indicated&#xa0;that HCWs are strongly motivated to contribute to xenotransplant research to impact change upon the greater scientific and healthcare community and for personal achievement or satisfaction. While about half of respondents reported at least one apprehension to participation, these apprehensions were abrogated after caring for xenotransplant recipients. Most respondents reported no barriers to future participation, but among those who reported at least one barrier, the risk of zoonosis transmission was the most frequent.</p> Summary <p>Despite reported apprehensions and potential barriers, most HCWs found the experience rewarding, felt that they&#xa0;impacted&#xa0;the overall success of the study, and would&#xa0;assist&#xa0;with future xenotransplant research.</p>

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Research with the Deceased: A Single Center Study of Healthcare Provider Attitudes and Perceptions

  • 期刊论文

  • 发表日期：

    2026年4月18日

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  • Grant Eickel,
  • Tal Eitan,
  • Juan Esteban Baus Davalos,
  • Grace Hammond,
  • Ian Jaffe,
  • Katya Kaplow,
  • Cecilia Deterville,
  • Christopher Hickson,
  • Shushaunna Bennett,
  • Keilee Luo,
  • Nikki Lawson,
  • Jacqueline Kim,
  • Rebecca Dieter,
  • Nader Moazami,
  • Aprajita Mattoo,
  • Vasishta Tatapudi,
  • Sapna A. Mehta,
  • Adam Griesemer,
  • Robert A. Montgomery,
  • Philip Sommer,
  • Macey Levan,
  • Kathleen Zavotsky,
  • Elaina Weldon,
  • Jeffrey Stern,
  • Karen Khalil

摘要

Purpose of Review

Understanding the attitudes and perceptions that healthcare workers (HCWs) hold towards xenotransplantation is necessary to ensure ongoing support in research and clinical settings. To date, there have been no survey studies on HCWs who participated in solid-organ xenotransplantation research, in either the decedent-model or a living patient.

Recent Findings

Two anonymous surveys were distributed to healthcare workers involved in the clinical management and coordination of pig-to-human xenokidney and xenoheart studies in brain-dead human decedents at a single institution. In total, 58 respondents were included, two-thirds of which exclusively provided direct medical care to the decedent while one-third exclusively provided operational or research support. Results indicated that HCWs are strongly motivated to contribute to xenotransplant research to impact change upon the greater scientific and healthcare community and for personal achievement or satisfaction. While about half of respondents reported at least one apprehension to participation, these apprehensions were abrogated after caring for xenotransplant recipients. Most respondents reported no barriers to future participation, but among those who reported at least one barrier, the risk of zoonosis transmission was the most frequent.

Summary

Despite reported apprehensions and potential barriers, most HCWs found the experience rewarding, felt that they impacted the overall success of the study, and would assist with future xenotransplant research.