Purpose of Review <p>Invariant Natural Killer T (iNKT) cells are innate-like T lymphocytes bridging innate and adaptive immunity. Their capacity for rapid, potent cytokine secretion and their enrichment in organs such as the liver and lungs position them as critical modulators of allograft outcomes. This review summarizes the current understanding of iNKT cell biology and their multifaceted roles in solid organ transplantation.</p> Recent Findings <p>Recent findings reveal multifaceted roles of iNKT cells in transplantation. They are key early mediators of ischemia-reperfusion injury, particularly in the liver and kidney, and also contribute to alloimmunity. They are also essential for immune defense against opportunistic viral and bacterial infections common in transplant recipients. In the specific context of transplantation, standard immunosuppressive strategies additionally impact iNKT cell numbers and function.</p> Summary <p>Existing evidence has shown that iNKT cells play a crucial role in solid organ transplantation. A better understanding of mechanistic pathways underlying their functional variabilities will facilitate translating iNKT-targeted therapies to benefit graft survival and transplant outcomes.</p>