Purpose of Review <p>This review aims to synthesize the current literature on how Community Health Workers (CHWs) are leveraging Artificial Intelligence (AI). By examining how CHWs are interacting with AI in healthcare settings, it seeks to propose novel research opportunities and identify critical challenges that, when addressed, can effectively enhance cardiovascular health outcomes for adults with limited health literacy.</p> Recent Findings <p>Most of the studies were conducted outside the United States. Very few presented empirical findings, addressed literacy, or discussed implications for cardiovascular disease.</p> Summary <p>We identified several opportunities for researchers and policymakers around CHW+AI efforts in cardiovascular health and health literacy. These opportunities range from testing their ability to bridge communication gaps in written and spoken language to improving CHWs skills related to AI literacy (e.g., ability to understand and effectively use AI tools), health literacy (e.g., the ability to find, understand, and use information and services to make informed health-related decisions), and understanding of strategies to promote cardiovascular health. However, more work needs to be done in the United States, and integrating AI introduces critical challenges that still have not been addressed.</p>