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<p>Chronic renal failure is an increasingly prevalent health problem in the world population. In its final stage, patients require dialysis to filter the blood, most commonly through hemodialysis. During this procedure, blood is withdrawn, filtered, and returned to the patient’s body through vascular access. The arteriovenous fistula (AVF) is one of the most recommended vascular accesses for treatment; however, it is also associated with a series of problems resulting from its creation and use. The present study aimed to investigate the influence of AVF geometry (anastomosis angle) on blood flow, particularly on the variations in system pressure and its correlation with possible pathophysiological problems. For this purpose, AVFs were constructed with an anastomosis angle ranging from 30° to 150°, and through experimental analysis on a systolic-diastolic pulse bench, the influence of this parameter on the flow conditions of the access was observed. The results demonstrated a reduction in pressure differential as the anastomosis angle increased, with values decreasing from 12.0&#xa0;kPa to 3.1&#xa0;kPa. Additionally, analysis of the system’s hydraulic grade line revealed greater energy dissipation associated with the anastomosis region of AVFs with angles greater than 90°, underscoring the need for further study of this region of access.</p>

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Influence of anastomosis angle on pressure conditions in ideal AVF models: in vitro study

  • 期刊论文

  • 发表日期：

    2026年2月2日

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  • Jonhattan Ferreira Rangel,
  • Willyam Brito de Almeida Santos,
  • Thércio Henrique de Carvalho Costa,
  • Kleiber Lima de Bessa,
  • José Daniel Diniz Melo

摘要

Chronic renal failure is an increasingly prevalent health problem in the world population. In its final stage, patients require dialysis to filter the blood, most commonly through hemodialysis. During this procedure, blood is withdrawn, filtered, and returned to the patient’s body through vascular access. The arteriovenous fistula (AVF) is one of the most recommended vascular accesses for treatment; however, it is also associated with a series of problems resulting from its creation and use. The present study aimed to investigate the influence of AVF geometry (anastomosis angle) on blood flow, particularly on the variations in system pressure and its correlation with possible pathophysiological problems. For this purpose, AVFs were constructed with an anastomosis angle ranging from 30° to 150°, and through experimental analysis on a systolic-diastolic pulse bench, the influence of this parameter on the flow conditions of the access was observed. The results demonstrated a reduction in pressure differential as the anastomosis angle increased, with values decreasing from 12.0 kPa to 3.1 kPa. Additionally, analysis of the system’s hydraulic grade line revealed greater energy dissipation associated with the anastomosis region of AVFs with angles greater than 90°, underscoring the need for further study of this region of access.