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Purpose <p>This study aimed to compare molar incisor hypomineralisation (MIH) prevalence and severity in children with sickle cell disease (SCD) versus healthy controls, whilst investigating associations with haematologic parameters and phenotypic disease expression.</p> Methods <p>A retrospective cohort study included 60 SCD children (6–14&#xa0;years) from a Brazilian haematology centre and 605 age-matched healthy controls, assessed between August 2022 and June 2023. Comprehensive dental examinations assessed MIH presence and severity. Laboratory investigations included complete blood count analysis (with erythroblast quantification) and phenotypic characterisation of SCD. Additional data collection encompassed dental anxiety, hypersensitivity, and aesthetic questionnaires for SCD participants. Statistical analysis employed chi-square, Mann–Whitney U, and Fisher's exact tests (α = 0.05).</p> Results <p>The SCD group demonstrated significantly higher MIH prevalence compared to control (63.3% vs. 18.2%; p &lt; 0.001) with a prevalence ratio of 3.48 (95% CI 2.66, 4.54). While severity distribution differed between groups (p &lt; 0.001), severe MIH was less frequent in SCD (6/60 vs 32/605 controls; prevalence ratio = 1.72, 95% CI 1.05, 2.81; p = 0.03). MIH in SCD showed strong associations with the vaso-occlusive phenotype (86.8% of cases, p &lt; 0.001) and reduced erythroblast counts (p = 0.014), but no significant correlations with demographic factors or reported dental symptoms.</p> Conclusion <p>Children with SCD showed a significantly higher prevalence of MIH compared with healthy controls. In the SCD group, MIH was associated with the vaso-occlusive phenotype and lower erythroblast counts.</p>

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High prevalence of molar-incisor hypomineralisation in sickle cell disease children and the association with haematologic profile: a retrospective cohort study

  • 期刊论文

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  • 发表日期：

    2026年6月18日

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  • Kelly Fernanda Molena,
  • Mariana Andrade Costa,
  • Alana Cândido Paulo,
  • Francisco Wanderley Garcia de Paula-Silva,
  • Raquel Assed Bezerra da Silva,
  • Karina Alessandra Michelão Grecca Pieroni,
  • Cristina Bueno Brandão,
  • Leda Regina Fernandes Mugayar,
  • Ana Cristina Silva Pinto,
  • Alexandra Mussolino de Queiroz,
  • Leandro Dorigan de Macedo,
  • Fabricio Kitazono de Carvalho

摘要

Purpose

This study aimed to compare molar incisor hypomineralisation (MIH) prevalence and severity in children with sickle cell disease (SCD) versus healthy controls, whilst investigating associations with haematologic parameters and phenotypic disease expression.

Methods

A retrospective cohort study included 60 SCD children (6–14 years) from a Brazilian haematology centre and 605 age-matched healthy controls, assessed between August 2022 and June 2023. Comprehensive dental examinations assessed MIH presence and severity. Laboratory investigations included complete blood count analysis (with erythroblast quantification) and phenotypic characterisation of SCD. Additional data collection encompassed dental anxiety, hypersensitivity, and aesthetic questionnaires for SCD participants. Statistical analysis employed chi-square, Mann–Whitney U, and Fisher's exact tests (α = 0.05).

Results

The SCD group demonstrated significantly higher MIH prevalence compared to control (63.3% vs. 18.2%; p < 0.001) with a prevalence ratio of 3.48 (95% CI 2.66, 4.54). While severity distribution differed between groups (p < 0.001), severe MIH was less frequent in SCD (6/60 vs 32/605 controls; prevalence ratio = 1.72, 95% CI 1.05, 2.81; p = 0.03). MIH in SCD showed strong associations with the vaso-occlusive phenotype (86.8% of cases, p < 0.001) and reduced erythroblast counts (p = 0.014), but no significant correlations with demographic factors or reported dental symptoms.

Conclusion

Children with SCD showed a significantly higher prevalence of MIH compared with healthy controls. In the SCD group, MIH was associated with the vaso-occlusive phenotype and lower erythroblast counts.