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Aim <p>Pediatric jaw lesions often present diagnostic challenges due to overlapping clinical and radiographic features.</p> Background <p>Among these, unicystic ameloblastoma (UA) and odontogenic keratocyst (OKC) are two distinct odontogenic entities with differingbiological behaviors and recurrence risk. However, a few cases may exhibit histopathological features of both, complicating definitivediagnosis and management.</p> Case Description <p>This paper presents a case of a 12-year-old boy with a mandibular lesion clinically suggestive of a dentigerous cyst based on clinicaland radiographical analysis. However, histopathological evaluation of the enucleated cystic lesion revealed intraluminal unicysticameloblastoma, with some areas showing features of odontogenic keratocyst.</p> Discussion <p>This unusual combination raises important diagnostic and therapeutic considerations, particularly in children where long-termoutcomes and recurrence risk must be weighed carefully.</p> Conclusion <p>The case emphasizes the critical role of histopathological evaluation and clinicopathological correlation of such ambiguous lesions inthe pediatric population as it helps to broaden the current understanding of odontogenic cystic lesions for appropriate treatment andoutcome.</p>

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Histopathological crossover between unicystic ameloblastoma and odontogenic keratocyst in 12-year-old: a case report with literature review

  • 期刊论文

  • 发表日期：

    2025年9月16日

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  • S. R. Nagar,
  • S. Ali,
  • M. Katarni,
  • S. S. Talkar

摘要

Aim

Pediatric jaw lesions often present diagnostic challenges due to overlapping clinical and radiographic features.

Background

Among these, unicystic ameloblastoma (UA) and odontogenic keratocyst (OKC) are two distinct odontogenic entities with differingbiological behaviors and recurrence risk. However, a few cases may exhibit histopathological features of both, complicating definitivediagnosis and management.

Case Description

This paper presents a case of a 12-year-old boy with a mandibular lesion clinically suggestive of a dentigerous cyst based on clinicaland radiographical analysis. However, histopathological evaluation of the enucleated cystic lesion revealed intraluminal unicysticameloblastoma, with some areas showing features of odontogenic keratocyst.

Discussion

This unusual combination raises important diagnostic and therapeutic considerations, particularly in children where long-termoutcomes and recurrence risk must be weighed carefully.

Conclusion

The case emphasizes the critical role of histopathological evaluation and clinicopathological correlation of such ambiguous lesions inthe pediatric population as it helps to broaden the current understanding of odontogenic cystic lesions for appropriate treatment andoutcome.