Background <p>The Deauville score (DS) on FDG-PET/CT is the standard for evaluating treatment response in Hodgkin Lymphoma (HL), but it’s qualitative and subjective. The standardized uptake value ratio (SUVR = SUVmax Lymphoma/SUVmax Liver) offers a more quantitative and objective assessment.</p> Objective <p>Compare DS and SUVR at end-of-treatment (EOT) FDG-PET/CT for progression-free survival (PFS) in HL.</p> Methods <p>Patients with classical HL had EOT-PET scans re-scored using DS and SUVR. Reciever operator curve (ROC) determined optimal SUVR cut-off. Sensitivity, specificity, positive and negative predictive values for DS (positive ≥ 4) and SUVR (positive ≥ 1.13) were computed. Kaplan-Meier curves and Cox-regression analyzed predictive ability for PFS.</p> Results <p>Among 154 patients (median age 31), the optimal SUVR cut-off was 1.13. DS and SUVR had identical diagnostic parameters. Both predicted PFS (Hazard Ratio 22.85 [95% CI 9.13–57.15]). The stage-specific SUVR cutoff was 1.40 for patients with limited favourable disease and 2.20 for patients with advanced disease. The stage-specific SUVR cut-off among patients with advanced disease resulted in improved specificity (92.6% vs. 98.8%) and positive predictive value (68.4% vs. 92.3%) compared to the DS.</p> Conclusion <p> <?tk 4?>SUVR (≥ 1.13) and DS are equally predictive of PFS at EOT, with SUVR offering a more objective assessment.</p>