<p>Statins are a cornerstone of secondary prevention following acute ischemic stroke (AIS). Widely used for their lipid-lowering effects, emerging evidence suggests the pleiotropic properties of statins provide a benefit in AIS management, including for patients with low baseline lipid levels. Established guidelines for statin therapy following AIS are inconsistent. Treatment optimization requires a personalised approach which considers stroke subtype and patient characteristics. Emerging strategies in statin care following AIS include novel drug-delivery systems improving bioavailability to the brain and combination therapies for patients with comorbid conditions or resistance to statin therapy.</p>

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Personalize statin therapy following acute ischemic stroke

  • Michael B. Brown

摘要

Statins are a cornerstone of secondary prevention following acute ischemic stroke (AIS). Widely used for their lipid-lowering effects, emerging evidence suggests the pleiotropic properties of statins provide a benefit in AIS management, including for patients with low baseline lipid levels. Established guidelines for statin therapy following AIS are inconsistent. Treatment optimization requires a personalised approach which considers stroke subtype and patient characteristics. Emerging strategies in statin care following AIS include novel drug-delivery systems improving bioavailability to the brain and combination therapies for patients with comorbid conditions or resistance to statin therapy.