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<p>There is no standard diagnostic criteria or treatment course for Stevens–Johnosn syndrome (SJS) and toxic epidermal necrolysis (TEN). Laboratory findings aid differentiation between SJS/TEN and other conditions with similar clinical features, although research into diagnostic biomarkers is ongoing. Cessation of the causative agent and aggressive multidisciplinary care is the mainstay of SJS/TEN treatment. Systemic therapy with pharmacological agents or plasmapheresis have demonstrated efficacy in open-label trials and case studies, although their use remains controversial. Clinical evaluation of systemic treatment of SJS/TEN is ongoing.</p>

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Consider systemic therapy alongside supportive care in the early phases of Stevens–Johnson syndrome/toxic epidermal necrolysis

  • 期刊论文

  • 发表日期：

    2025年9月26日

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  • Michael B. Brown

摘要

There is no standard diagnostic criteria or treatment course for Stevens–Johnosn syndrome (SJS) and toxic epidermal necrolysis (TEN). Laboratory findings aid differentiation between SJS/TEN and other conditions with similar clinical features, although research into diagnostic biomarkers is ongoing. Cessation of the causative agent and aggressive multidisciplinary care is the mainstay of SJS/TEN treatment. Systemic therapy with pharmacological agents or plasmapheresis have demonstrated efficacy in open-label trials and case studies, although their use remains controversial. Clinical evaluation of systemic treatment of SJS/TEN is ongoing.