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<p>Tegileridine (艾苏特) is a novel postoperative analgesic option indicated for moderate-to-severe postoperative pain in China. Tegileridine is a biased µ-opioid receptor agonist with minimal β-arrestin-2 activation relative to morphine and may therefore provide effective analgesia with a lower risk of opioid-related adverse effects such as respiratory depression and gastrointestinal dysfunction. In phase 3 trials, tegileridine significantly reduced pain intensity in adult patients with moderate-to-severe postoperative pain following abdominal or orthopaedic surgeries. Tegileridine was generally well tolerated, with nausea and vomiting being the most common adverse events.</p>

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Tegileridine in postoperative pain: a profile of its use

  • 期刊论文

  • 发表日期：

    2025年7月11日

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  • Michael B. Brown,
  • Yahiya Y. Syed

摘要

Tegileridine (艾苏特) is a novel postoperative analgesic option indicated for moderate-to-severe postoperative pain in China. Tegileridine is a biased µ-opioid receptor agonist with minimal β-arrestin-2 activation relative to morphine and may therefore provide effective analgesia with a lower risk of opioid-related adverse effects such as respiratory depression and gastrointestinal dysfunction. In phase 3 trials, tegileridine significantly reduced pain intensity in adult patients with moderate-to-severe postoperative pain following abdominal or orthopaedic surgeries. Tegileridine was generally well tolerated, with nausea and vomiting being the most common adverse events.