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<p>Sarcopenia is an age-associated muscle disease characterised by a loss of skeletal muscle function and mass, and resulting in an increased risk of falls and fractures. It is treated with resistance exercises and diet optimisation; however, these interventions are not suitable for all patients. Currently, no pharmacotherapies are approved for the treatment of sarcopenia. Both hormonal and non-hormonal drugs have been considered; testosterone and BIO101 each have growing bodies of evidence as potential therapies for sarcopenia, but they require further studies, particularly in sarcopenic patients. The clinical evidence supporting the use of other drugs is varied and sometimes conflicting.</p>

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Continue to treat sarcopenia with exercise and diet while potential pharmacotherapies are under investigation

  • 期刊论文

  • 发表日期：

    2025年2月28日

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  • Aisling McGuigan

摘要

Sarcopenia is an age-associated muscle disease characterised by a loss of skeletal muscle function and mass, and resulting in an increased risk of falls and fractures. It is treated with resistance exercises and diet optimisation; however, these interventions are not suitable for all patients. Currently, no pharmacotherapies are approved for the treatment of sarcopenia. Both hormonal and non-hormonal drugs have been considered; testosterone and BIO101 each have growing bodies of evidence as potential therapies for sarcopenia, but they require further studies, particularly in sarcopenic patients. The clinical evidence supporting the use of other drugs is varied and sometimes conflicting.