Scholarlink

<p>This review summarizes the evolution of aryne generation methodologies, from early harsh approaches to recent mild and practical strategies. It aims to provide a systematic overview of advances over the past decade, with particular emphasis on the last five years. Key methods discussed include activation using bulky bases, cyclic onium salts, photochemical triggers, ring-opening of four-membered rings, and transition-metal-assisted processes. These modern techniques enable aryne formation under milder conditions, with improved functional group tolerance, operational safety, and scalability. As a result, arynes have become versatile tools for constructing complex aromatic molecules, modifying pharmaceuticals, and performing bioorthogonal reactions. The review concludes by highlighting future directions, such as developing more accessible precursors, discovering new reaction modes, and expanding applications in drug discovery, materials science, and chemical biology.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Recent Advances in Aryne Generation Methods: From Classical Strategies to Cutting-edge Breakthroughs

  • 期刊论文

  • 发表日期：

    2026年7月4日

查看全文
  • Wenhao Yin,
  • Dachuan Qiu,
  • Yang Li

摘要

This review summarizes the evolution of aryne generation methodologies, from early harsh approaches to recent mild and practical strategies. It aims to provide a systematic overview of advances over the past decade, with particular emphasis on the last five years. Key methods discussed include activation using bulky bases, cyclic onium salts, photochemical triggers, ring-opening of four-membered rings, and transition-metal-assisted processes. These modern techniques enable aryne formation under milder conditions, with improved functional group tolerance, operational safety, and scalability. As a result, arynes have become versatile tools for constructing complex aromatic molecules, modifying pharmaceuticals, and performing bioorthogonal reactions. The review concludes by highlighting future directions, such as developing more accessible precursors, discovering new reaction modes, and expanding applications in drug discovery, materials science, and chemical biology.