<p>Recently, considerable effort has been devoted to the development of stimuli-responsive supramolecular room temperature phosphorescence (RTP) materials due to their potentials in information encryption, data storage, sensing and biological imaging. Compared to fluorescence, the construction of stimuli-responsive RTP materials faced greater challenges, as it requires both the stabilized triplet excitons and responsive sites. In this review, we categorize and summarize several types of stimuli-responsive RTP materials, aiming to elucidate the relationship between external stimuli and phosphorescence mechanisms. The common features and principles provide guidelines for the designing and construction of new smart RTP materials. Finally, certain limitations in the current design and mechanistic study of stimuli responsive RTP materials are discussed and the wide application prospects of stimuli-responsive RTP materials are highlighted.</p>