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<p>Mitochondrial ATP synthase (MAS), an enzyme responsible for ATP production referred to as complex V, plays a crucial role as the ultimate enzyme in the mitochondrial oxidative phosphorylation (OXPHOS) pathway. In the context of breast cancer (BC) progression and metastasis, the elevated expression of ATP5F1A has been associated with disease progression, suggesting its potential relevance in BC. Changes in ATP levels also reflect the progression of carcinogenesis, providing insights into the characterisation of the tumour site and its surrounding microenvironment. Furthermore, the accumulation of mutations in genes encoding MAS underscores its involvement in the biological processes of cancer cell development throughout carcinogenesis. The primary objective of this study is to investigate the expression profile of ATP5F1A in BC and evaluate its therapeutic potential. In the current study, we employed an in silico approach to analyze the expression patterns of ATP5F1A in BC. Additionally, we explored its potential interactions and functional associations to better understand its possible role in BC pathogenesis. Our findings suggest that ATP5F1A is increased in several cancers, including BC. Our findings also suggest that ATP5F1A inhibition may influence therapeutic response, as compared to therapies where overexpression of ATP5F1A promotes tumour formation. Overall, our study suggests that increased expression of ATP5F1A contributes to BC progression. Quercetin showed dose-dependent cytotoxic effects in BC cells and showed potential binding to ATP5F1A in in-silico, which may represent a potential strategy to enhance therapeutic response in BC, warranting further investigation.</p>

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Expression and potential role of ATP5F1A in breast cancer through an integrated in silico and in vitro approach

  • 期刊论文

  • 发表日期：

    2026年5月26日

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  • Tabish Javeed,
  • Nusrat Jan,
  • Shazia Sofi,
  • Gowhar Masoodi,
  • Manzoor Ahmad Mir

摘要

Mitochondrial ATP synthase (MAS), an enzyme responsible for ATP production referred to as complex V, plays a crucial role as the ultimate enzyme in the mitochondrial oxidative phosphorylation (OXPHOS) pathway. In the context of breast cancer (BC) progression and metastasis, the elevated expression of ATP5F1A has been associated with disease progression, suggesting its potential relevance in BC. Changes in ATP levels also reflect the progression of carcinogenesis, providing insights into the characterisation of the tumour site and its surrounding microenvironment. Furthermore, the accumulation of mutations in genes encoding MAS underscores its involvement in the biological processes of cancer cell development throughout carcinogenesis. The primary objective of this study is to investigate the expression profile of ATP5F1A in BC and evaluate its therapeutic potential. In the current study, we employed an in silico approach to analyze the expression patterns of ATP5F1A in BC. Additionally, we explored its potential interactions and functional associations to better understand its possible role in BC pathogenesis. Our findings suggest that ATP5F1A is increased in several cancers, including BC. Our findings also suggest that ATP5F1A inhibition may influence therapeutic response, as compared to therapies where overexpression of ATP5F1A promotes tumour formation. Overall, our study suggests that increased expression of ATP5F1A contributes to BC progression. Quercetin showed dose-dependent cytotoxic effects in BC cells and showed potential binding to ATP5F1A in in-silico, which may represent a potential strategy to enhance therapeutic response in BC, warranting further investigation.