Scholarlink

Background <p>To investigate the relationship between extracellular water to total body water ratio (ECW/TBW) and mortality risk in type 2 diabetes mellitus (T2DM).</p> Methods <p>In this observational study, the effect of ECW/TBW, assessment by multi-frequency bioelectrical impedance analyzer, for whole body and arm, trunk, and leg, on all-cause mortality was evaluate by Cox proportional hazards regression. Covariates from prior evidence were sequentially added to the model and discrimination was assessed by AUC at 36, 60, and 84 months.</p> Results <p>Among 856 adults, 58.7% were male and mean (standard deviation (SD)) age, BMI, and HbA1c were 67.2 (12.0) years, 24.8 (4.7) kg/m² and 7.5 (1.3) %, respectively. During 49.1 (39.1) months follow-up, 42 individuals died. ECW/TBW was associated with higher mortality risk in all segments (adjusted hazard ratio (aHR) of Δ 1SD for whole body, arm, trunk and leg were1.81, 1.68, 1.49, and 2.29, respectively, all <i>p</i> &lt; 0.001). Adding ECW/TBW of whole body to the prespecified clinical model improved AUC (from 0.885 to 0.911 (ΔAUC 0.026, <i>p</i> = 0.018) in 36 months, from 0.874 to 0.898 (ΔAUC 0.024, <i>p</i> = 0.015) in 60 months, and from 0.893 to 0.916 (ΔAUC 0.023, <i>p</i> = 0.002) in 84 months).</p> Conclusion <p>ECW/TBW measurements of the whole body and trunk improved the ability to distinguish mortality risk in T2DM.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Extracellular water to total body water ratio as a predictor of all-cause mortality in type 2 diabetes

  • 期刊论文

  • 发表日期：

    2026年7月8日

查看全文
  • Shinta Yamamoto,
  • Yoshitaka Hashimoto,
  • Fuyuko Takahashi,
  • Moe Murai,
  • Nozomi Yoshioka,
  • Yuto Saijyo,
  • Chihiro Munekawa,
  • Hanako Nakajima,
  • Noriyuki Kitagawa,
  • Takafumi Osaka,
  • Ryosuke Sakai,
  • Hiroshi Okada,
  • Naoko Nakanishi,
  • Saori Majima,
  • Emi Ushigome,
  • Masahide Hamaguchi,
  • Michiaki Fukui

摘要

Background

To investigate the relationship between extracellular water to total body water ratio (ECW/TBW) and mortality risk in type 2 diabetes mellitus (T2DM).

Methods

In this observational study, the effect of ECW/TBW, assessment by multi-frequency bioelectrical impedance analyzer, for whole body and arm, trunk, and leg, on all-cause mortality was evaluate by Cox proportional hazards regression. Covariates from prior evidence were sequentially added to the model and discrimination was assessed by AUC at 36, 60, and 84 months.

Results

Among 856 adults, 58.7% were male and mean (standard deviation (SD)) age, BMI, and HbA1c were 67.2 (12.0) years, 24.8 (4.7) kg/m² and 7.5 (1.3) %, respectively. During 49.1 (39.1) months follow-up, 42 individuals died. ECW/TBW was associated with higher mortality risk in all segments (adjusted hazard ratio (aHR) of Δ 1SD for whole body, arm, trunk and leg were1.81, 1.68, 1.49, and 2.29, respectively, all p < 0.001). Adding ECW/TBW of whole body to the prespecified clinical model improved AUC (from 0.885 to 0.911 (ΔAUC 0.026, p = 0.018) in 36 months, from 0.874 to 0.898 (ΔAUC 0.024, p = 0.015) in 60 months, and from 0.893 to 0.916 (ΔAUC 0.023, p = 0.002) in 84 months).

Conclusion

ECW/TBW measurements of the whole body and trunk improved the ability to distinguish mortality risk in T2DM.